PROJECT INFORMATION
Host institution: Medical University of Vienna
Country: Austria
Supervisory team: Prof. Clemens Aigner, Doz. Alberto Benazzo, Dr. Alexis Slama (all Medical University of Vienna), Prof Edouard Sage (Hôpital Foch)
PROJECT DESCRIPTON
The objectives are: 1. Develop a target gene vector delivery model utilizing isolated lung perfusion (ILP). 2. Optimize ILP model for prolonged perfusion periods. 3. Identify potential targets for immunomodulation and assess effects of gene therapeutic agents on donor and recipient lungs.
The project will involve experiments in a human ILP model and collection and analysis of human clinical samples. Participating in the preparation of scientific publications and presentations.
A successful project will result in: Standardized human ILP platform allowing prolonged perfusion periods and establishment of a target gene vector delivery model. This model will be used assess effects of GTA on healthy and diseased lungs. The research aims to improve diagnostic tools and therapeutic strategies in lung transplantation.
Enrolment in Doctoral School: PhD Program, Medical University of Vienna
Planned secondments:
• Aarhus Universitet, Aarhus, Denmark: GTA delivery methods/CRISPR, acquaintance with technique (month 9)
• Ominscope Espana SL, Spain: Single cell resolution for high-definition T cell repertoire profiling (month 13)
• KUL, Leuven, Belgium: in vivo GTAs in mouse models (months 20-21)
ESSENTIAL REQUIREMENTS
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You hold a Master’s degree (no PhD) in bioengineering, biomedical sciences, biotechnology, pharmacy or a related field, or an MD
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You are passionate about life sciences and engineering, and want to achieve a PhD degree on the topic described in the description above
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You are ambitious, well organized and have excellent communication skills
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You are proficient in English both spoken and written
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You have a solutions-oriented mindset that thrives in a multidisciplinary team
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You have the ability to work independently and have a critical mindset
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You are an enthusiastic and motivated person, eager to participate in network-wide training events, international travel and public awareness activities
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Willingness to travel
DESIRABLE SKILLS AND EXPERTISE
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Experience with gene editing
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Understanding of pulmonary pathophysiology
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Familiarity with data processing, analysis and statistics