University College London

UCL has a global reputation for excellence in research and is committed to delivering impact and innovations that enhance the lives of people in the UK, across Europe and around the world. UCL was identified by the UK Research Excellence Framework as the top university in the UK for research strength, and UCL is consistently placed in the global top 20 across a wide range of university rankings. UCL Great Ormond Street Institute of Child Health together with its clinical partner Great Ormond Street Hospital for Children forms the largest concentration of children’s health research in Europe. The institute mission is to improve the health and wellbeing of children, and the adults they will become, through world-class research, education and public engagement. Within the Institute of Child Health, the research group of Prof. Stephen Hart investigates non-viral approaches to gene therapy of respiratory diseases such as cystic fibrosis and primary ciliary dyskinesia, as well as other diseases such as neuroblastoma cancers. In this work he has developed novel primary cell models, and novel nanoparticles delivering therapeutic nucleic acids including pDNA, siRNA, mRNA and CRISPR Cas9 gene editing formulations.